Identification of contaminating Clostridium spores as the oncolytic agent in some chalone preparations.
نویسندگان
چکیده
Crude concentrates of epidermal chalone from pig skin in some cases have shown striking oncolytic activity in melanomata in hamsters and mice. Attempts to purify this antitumor factor by biochemical methods failed. A correlation of epidermal or melanocytic chalone activity in vitro and oncolytic activity in vivo was absent. From fluid collected from lysing tumors spore-forming bacteria could be isolated and classified as Clostridium. It could be proved that the oncolytic activity in the active pig skin fractions is caused by contaminating spores of these clostridia.
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ورودعنوان ژورنال:
- Cancer research
دوره 32 6 شماره
صفحات -
تاریخ انتشار 1972